Landmark Human Trial: Vitamin REWINDS Your Cells Overnight!

Date: November 7 2025 | Reading Time: 2mn 30s

Researchers at Chiba University have discovered that nicotinamide riboside (NR), a vitamin B3 derivative that boosts NAD+ levels, can reverse several symptoms of early aging in humans. The clinical trial focused on Werner syndrome, a rare condition that causes rapid aging, skin ulcers, and early heart disease.

In a double-blind, placebo-controlled study, patients taking NR for six months showed higher NAD+ levels, better artery flexibility, faster wound healing, and improved kidney health, with no serious side effects. Scientists believe restoring NAD+ helps cells repair damage and maintain energy, addressing one of the key drivers of aging.

This research marks the first successful human trial of NR in a premature aging disorder and supports its growing reputation as a safe NAD+ booster with potential applications for age-related decline and healthspan optimization.

🧬 Quote from the Research Team

“Our results show that boosting NAD⁺ with NR can improve cardiovascular, skin, and kidney health — giving new hope to patients and insight into healthy aging,”
— Dr. Masaya Koshizaka, Chiba University

Sources References

https://www.cn.chiba-u.jp/en/news/press-release_e250605/ 

https://www.sciencedaily.com/releases/2025/06/250609020625.htm

https://www.sciencedaily.com/releases/2023/10/231018161914.htm

https://www.sciencedaily.com/releases/2021/01/210119114405.htm